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David Grandy papers

 Collection
Identifier: 2011-017

Scope and Contents

This collection contains an exhaustive amount of records showing the extensive and intensive work of the Grandy Lab in its research into the brain chemistry of the neurotransmitters called dopamine. In the course of decades-long studies, new types of dopamine were discovered, and more information came to light on their effects on such things as locomotor activity, learning, and memory which led to hope that they might be manipulated to help cure physical motor disorders, as well as a variety of mental disorders.

"Series I: Classes" - This series contains class curricula and other materials. It is subdivided into those classes he took himself and those he taught or reviewed later in his career. The materials include aeronautical engineering texts, college notebooks and exams, class reviews, and evaluations of both students and staff.

"Series II: Collected writings" is divided into abstracts, manuscripts, published articles, and book chapters collectively written by the Grandy Lab, as well as Grandy’s reviews of other peoples’ work.

"Series III: Departmental records" contains a plethora of materials outlining Grandy’s professional activities as a researcher and faculty member. It includes intra-departmental correspondence; experimental protocols; Grandy’s own personnel evaluations and those of his subordinates; reports on and from genetic analytical and pharmaceutical companies; financial materials; and descriptions of and requests for laboratory equipment.

"Series IV: Experimental and research data" is the largest series of the collection and contains mountains of raw data and media in files, lab notebooks, and reports showing the exhausting thoroughness of the lab’s genetic analyses over the years.

"Series V: General correspondence" is non-departmental correspondence of Grandy with colleagues and correspondents around the country and across the globe.

"Series VI: Grants" includes documentation of the grants funding the Grandy Lab’s multitude of research projects over the years.

"Series VII: Media" consists of a wide variety of media. These include chromatographs, drawn graphics, film strips, micrographs, photographs, negatives, radiographs, transparencies, and videotapes. Such computer media as was accessible has been transferred to our digital archives, but is not currently available online.

"Series VIII: Patents" includes the documentation about the great amount of new technologies and products the Laboratory’s studies created in the course of its research into DNA cloning.

Dates

  • Creation: 1963-2016

Creator

Conditions Governing Access

There are no restrictions on access. This collection is open to the public.

Conditions Governing Use

OHSU Historical Collections & Archives (HC&A) is the owner of the original materials and digitized images in our collections, however, the collection may contain materials for which copyright is not held. Patrons are responsible for determining the appropriate use or reuse of materials. Consult with HC&A to determine if we can provide permission for use.

Biographical note

David Kilgore Grandy was born in Ohio on March 19, 1952. In high school he showed an early aptitude for aeronautical engineering through Boy Scouts by participating in the NASA sponsored Lewis Aerospace Explorers in Cleveland, OH. He later gravitated to biology, gaining his B.S. in that field at Wooster College (OH) in 1974 and his M.S. from Case Western Reserve University in 1978. He also worked as a lab assistant in their respective Biology departments. After a couple of years of post-graduate work as lab assistant at the Cleveland Clinic Foundation, he did doctoral work at Michigan State University (Ph.D., 1985) where he was affiliated with the Department of Microbiology & Public Health. During this period, he also studied molecular cloning at New York’s Cold Spring Harbor Laboratory.

Grandy came west to Oregon for his post-doctoral work in Molecular Neurobiology as a winner of a National Institute on Drug Abuse National Research Service Award. He joined OHSU’s Vollum Institute for Advanced Biomedical Research as a Senior Research Associate where he began decades-long research into the neurotransmitter called dopamine. Dopamine was considered to be essential in the creation of adrenaline, learning, memory, motor control, and the brain’s reward system (motivation). Theories were explored linking dopamine depletion to such disorders as Parkinson’s Disease, ADHD, schizophrenia, and drug addiction.

His laboratory won many Federal grants, and their experiments in DNA cloning resulted in many technology patents and business deals that enhanced their and the University’s reputation, as well as their economic bottom line. In time, Grandy became faculty in the departments of Cell Biology & Anatomy, Physiology & Pharmacology, and later, Anesthesiology as well.

In his extracurricular activities, Dr. Grandy has been active for many years in the non-profit ministry outreach “Operation Nightwatch,” reaching out to underserved communities such as the homeless, the mentally challenged, those with addictions, and at-risk youth. He has been on the Board of Directors since 2010.

Extent

28.5 Linear Feet

Language of Materials

English

Abstract

This collection consists of the research work of David K. Grandy, Ph.D. in the field of brain chemistry, with specific concentration on the neurotransmitter called dopamine.

Arrangement

The collection is divided into eight major series: Classes (with subseries for classes Grandy took as a student and those he taught himself); Collected writings (with subseries for Abstracts, Manuscripts, Published articles and book chapters, and Reviews); Departmental records (with subseries for Records and documentation, and Day planners and calendars); Experimental and research data; General correspondence; Grants; Media (with subseries for Graphic media, Slides, and Transparencies); and Patents. Files are arranged chronologically, and within specific years, alphabetically. Names are alphabetic by surname.

Acquisition

Materials were transfered to HC&A directly from Dr. David Grandy in multiple accessions from 2011 to 2018.

Title
Guide to the David Grandy papers
Status
Completed
Author
Jeff Colby
Date
2019
Description rules
Describing Archives: A Content Standard
Language of description
English
Script of description
Latin
Language of description note
Finding aid written in English.

Repository Details

Part of the Oregon Health & Science University, Historical Collections & Archives Repository

Contact:
3181 SW Sam Jackson Park Road
MC: LIB
Portland OR 97239 United States